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Risks and considerations "Compared with placebo and active comparator, semaglutide induces mostly mild and transient gastrointestinal disturbances and increases the risk of cholelithiasis." 16 It does not alter the levels of commonly used medications like HRT, metformin, or diuretics

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Common Side Effects Semaglutides common side effects are typically mild and often resolve over time: Nausea : Frequently experienced when starting or increasing the dose

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But more importantly, it's shown to modulate satiety signals and boost fat oxidation

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